Postdoc in RNA Regulation and Neurodegeneration Research
Posted on December 20, 2024
We are seeking a highly motivated postdoctoral researcher to join our dynamic team focused on studying RNA regulation in neurodegeneration. Axonal loss is the earliest indicator of degeneration in various disorders, and our goal is to uncover the mechanisms behind axonal vulnerability. Our research specifically targets two motor neuron disorders: Amyotrophic Lateral Sclerosis (ALS) and Charcot-Marie-Tooth disease (CMT).
About the Project: You will be working with human-induced pluripotent stem cells (hiPSCs)-based models of neurodegeneration, utilizing cutting-edge systems biology and imaging techniques, as well as compartmentalized neuronal cultures. This research will build upon our lab's existing work (Loedige et al. Molecular Cell 2023; Mendonsa et al. Nature Neuroscience 2023; Mendonsa et al. NAR 2021; Ludwik et al. Methods 2019; Zappulo et al. Nature Comm 2017). For more information on our research, please visit our website.
Ideal Candidate: We are looking for a highly motivated researcher with experience in molecular biology techniques. Previous expertise in RNA biology, hiPSC culture, and neurodegeneration is advantageous.
How to Apply: To apply, please send your motivation letter and CV, including contact information for at least two referees, as a single PDF file to [email protected]. We look forward to receiving your application!
Suggested Readings:
1. von Kuegelgen et al. "Neuromuscular dysfunction in patient-derived FUSR244RR-ALS iPSC model via axonal downregulation of neuromuscular junction proteins." biorxiv, 2024 https://doi.org/10.1101/2024.08.17.607965
2. Loedige I., et al. "mRNA stability and m6A as major influencers of subcellular mRNA localization in neurons." Molecular Cell, 2023 https://doi.org/10.1016/j.molcel.2023.06.021
3. Mendonsa S., et al. "Massively parallel identification of mRNA localization elements in primary cortical neurons." Nature Neuroscience, 2023 https://www.nature.com/articles/s41593-022-01243-x
4. Mendonsa S., et al. "Charcot-Marie-Tooth mutation and its effects on ribosomal stalling and stress response activation." Nucleic Acids Research, 2021 https://doi.org/10.1093/nar/gkab730
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