Open Postdoctoral Position - Yale University, USA

Posted on March 17th, 2025

The Nicoli Lab is seeking a highly motivated Postdoctoral Researcher with expertise in RNA biology to investigate localized mRNA processes— such as selective translation, transport, phase separation, and localization—that enable cells to respond to mechanical stimuli.

This project will explore RNA-based regulatory mechanisms in mechanotransduction, aiming to understand how the regulation of mRNAs influences cell behavior in response to extracellular matrix and blood flow-induced hemodynamics. Ultimately, our goal is to uncover how mRNA can serve as a building block for tissue engineering and regenerative therapies, with applications in stem cell development, wound healing, and cardiovascular disease treatment.

Key Responsibilities:

• Design and conduct experiments on post-transcriptional mRNA regulation in the context of cell biology and tissue ex-vivo and in vivo mechanotransduction.
• Investigate RNA-mediated processes governing cellular responses to mechanical cues.
• Utilize advanced molecular and imaging techniques to study RNA localization and function.
• Collaborate within a multidisciplinary team at the intersection of RNA biology and biomechanics.
• Present findings in scientific conferences and author top notch publications.

Qualifications:

• PhD in Molecular Biology, RNA Biology, Biophysics, or a related field.
• Strong background in RNA biology, gene regulation, or mechanotransduction.
• Experience with RNA imaging, ribosome profiling, or related transcriptomic techniques.
• Excellent problem-solving skills and ability to work independently.

If you are excited about unraveling RNA-driven mechanisms in cellular responses to mechanical forces, we encourage you to apply!

To apply, please send your CV, a brief cover letter, and contact information for three references to [email protected]